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Regulation of TGF- family signaling by E3 ubiquitin ligases

J Biol Chem (2004) 279(5):35737

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A significant decrease in LV mass, interstitial collagen and collagen concentration was demonstrated with chronic HEX treatment (for 21 days), accompanied by a decrease in TGF1 expression, myofibroblast differentiation and an increase in collagendegrading MMP13 expression levels